Narcolepsy (part 8)

… continued from previous seven articles on narcolepsy, where in the recent one the effects of Sodium Oxybate (Xyrem®) were mentioned.

In this week’s article, I will discuss the effects of Modafinil (Provigil®) and Amphetamines on the body.

Modafinil (Provigil®): (1)

Through research I came across the MHRA warnings which were:

  • Avoid intake if one is: under the age of eighteen, has uncontrolled hypertension, cardiac arrhythmias or is pregnant/ breast-feeding.
  • Take care if history of psychosis, depression, or mania, alcohol or substance abuse has been present.
  • Discontinue it in case of serious skin/ hypersensitivity reactions or has psychiatric disorders such as suicidal ideation.
  • Take a baseline electrocardiogram pre-treatment as well as during treatment and it is vital to monitor the blood pressure, heart rate/rhythm. Afterwards, do a comparison and if the results are abnormal, then stop the treatment.


Amphetamines: (2)

The doctors began using it in the 1960s for depression and obesity but they were initially developed in the 1920s. Nowadays, they are usually only prescribed to those with certain types of hyperactivity in children or uncontrolled sleeping such as narcolepsy. The use of amphetamines is illegal due to the increased feelings of confidence, comfort, happiness and alertness that are caused by the drug. Long terms risks include: malnutrition, psychotic episodes and difficulty sleeping. After a while of using amphetamines, those using the drug would feel the need to increase the dosage to produce the feelings they initially experienced when they started using the drug.

To be continued…


(1). Imm, N. and Willacy, H. (2016). Narcolepsy and Cataplexy. Medical information. | Patient. [online] Patient. Available at: [Accessed 12 Apr. 2016].
 (2). (2016). RISKS OF RECREATIONAL DRUG USE – Family Doctor. [online] Available at: [Accessed 12 Apr. 2016].



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